Help protect your eyes from oxidative stress and damage
The onset of dry eye is attributed to an inflammation resulting from an increased amount of reactive oxygen species (ROS) in the corneal epithelial cells; the damage to corneal epithelial cells decreases the stability of the tear film layer. Thus, antioxidants have the potential to ease dry eye symptoms
Anti-inflammatory and anti-oxidative therapies are considered as causative therapeutic approaches for dry eye symptoms, since they aim at interrupting the underlying vicious circle, rather than providing just a symptomatic temporary relief.
In recent years, there has been growing interest in the potential role of nutraceuticals to decrease dry eye symptoms. Numerous in vitro and in vivo studies have demonstrated the beneficial effect of certain dietary constituents on the ocular surface system health
Pals Toptear liquid filled capsules, uniquely combines four powerful herbal ingredients, of which two of these have been clinically studied and shown to decrease dry eye symptoms, the other two ingredients have been clinically tested for their powerful anti-inflammatory properties.
One of the main ingredients in Pals Toptear is MaquiBright®, a patented maqui berry extract standardized to bear a minimum of 25% delphinidins and a minimum of 35% total anthocyanins.
When the eye suffers from dry eye symptoms, it lacks nutrition and protection. In a study performed with cells of the lacrimal gland, it was shown that MaquiBright® was able to penetrate this tissue and suppress inflammatory processes caused by oxidative stress, restoring the normal production of tears.
MaquiBright® has shown significant effects on the increase of tear production and the decrease of bothersome ocular discomforts in clinical studies.
Participants (N=74) using MaquiBright® showed an increase of 89 % in tear fluid production after 4 weeks.
A Dry Eye-Related Quality-of-Life Score questionnaire (DEQS) could demonstrate that participants (N=74) using MaquiBright® reported a significant amelioration of 57 % in bothersome ocular discomforts after 4 weeks.
A Dry Eye-Related Quality-of-Life Score questionnaire (DEQS) could demonstrate that participants (N=74) using MaquiBright® reported a significant amelioration of 57 % in bothersome ocular discomforts after 4 weeks.
Another big player in Pals Toptear, is the high potency Branded and full spectrum Bilberry extract Mirtoselect®, rich in anthocyanins. Anthocyanins are found naturally in a number of foods - in red wine, certain varieties of cereals, and certain leafy and root vegetables (aubergines, cabbage, beans, onions, radishes) - but are most abundant in coloured fruits like bilberries.
Furthermore, it has been reported in The Journal of Agriculture and Food Chemistry that Vaccinium myrtillus L. (Bilberry) contain higher amounts of anthocyanins than any other berries.
Mirtoselect® is a standardized bilberry extract containing ≥36% of anthocyanins, and is characterized by a very specific and consistent HPLC profile that represents the “fingerprint” of the extract. Mirtoselect® is the authentic bilberry extract (Vaccinium myrtillus L.) obtained exclusively from fresh fruit harvested when ripe, between July and September.
The Mirtoselect® extract is the most studied bilberry ingredient on the market. The major applications investigated so far for Mirtoselect® are in the realms of vascular health and ophthalmology (retinal health).
Through the beneficial effect on vascular circulation, Mirtoselect® can improve oxygen and blood delivery to the eye, restoring the functionality of tear secretion. Furthermore, the free radical scavenging properties counteract oxidative stress, one of the major risk factors of dry eye discomfort.
Positive data has emerged regarding the supportive role of Mirtoselect® in eye health, in particular dry eye conditions. A randomized, double-blinded, placebo-controlled clinical study offers further proof of the efficacy and safety profile of Mirtoselect®, where preserving adequate tear levels and maintaining the ocular surface healthy may possibly help in attenuating discomfort and visual disturbance.
Today Mirtoselect® is the only bilberry extract (Vaccinium myrtillus L.) supported by clinical data on dry eye condition and is the oldest, most renowned clinically-studied bilberry extract on the market.
Pals Toptear Maqui Berry MaquiBright® and Bilberry MirtoSelect® offer antioxidants from different berries that can be complementary and synergistic in their benefit. Additionally, MaquiBerry offers naturally-occurring omegas that are complementary in the dry eye relief.
In addition to the aforementioned, Pals Toptear is formulated with our flagship ingredient Curcumin (Curcugen®) and KSM 66 Ashwagandha, which have both been studied for their anti-inflammatory effects, thus resulting in a superior formula to ease dry eye symptoms.
Furthermore, Pals Toptear is formulated in liquid filled vegan capsules, versus the typical powder.
Liquid has been shown to dissolve more rapidly into your cells, providing a higher potency and absorption rate, which brings you real healthy results.
Best of all, you just need ONE (1) capsule a day! Try Pals Toptear today and give your eyes the comfort it deserves.
